Read Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory)

Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory)

Karl S. Matlin

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Description:A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning, the relationship between structure and function, allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory). To get started finding Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory), you are right to find our website which has a comprehensive collection of manuals listed.
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ISBN: 0226819345

Description: A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning, the relationship between structure and function, allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory). To get started finding Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory), you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory)

Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology (Convening Science: Discovery at the Marine Biological Laboratory)

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