Read Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family

Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family

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Description:The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. *Includes a database for Ras family proteins and their effectors and regulators *Complimentary to volume 406 coverage of the Rho family *Over 150 international contributorsWe have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family. To get started finding Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family, you are right to find our website which has a comprehensive collection of manuals listed.
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Pages: 824

Format: PDF, EPUB & Kindle Edition

Publisher: Academic Press

Release: 2006

ISBN: 1280635819

Description: The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. *Includes a database for Ras family proteins and their effectors and regulators *Complimentary to volume 406 coverage of the Rho family *Over 150 international contributorsWe have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family. To get started finding Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family

Methods in Enzymology, Volume 407: Regulators and Effectors of Small Gtpases: Ras Family

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