Read The Biology of Extracellular Molecular Chaperones

The Biology of Extracellular Molecular Chaperones

Unknown Author

4.9/5 (30762 ratings)

Description:The heat shock, or cell stress, response was first identified in the polytene chromosomes of "Drosophila." This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.Since the promulgation of the 'molecular chaperone' concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.This is the first book bringing leading researchers in this field together to review and discuss: our current knowledge of cell stress response and molecular chaperonesthe changing paradigms of protein trafficking and functioncell stress proteins as immunomodulators and pro- and anti-inflammatory signalling moleculesthe role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents."The Biology of Extracellular Molecular Chaperones" is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with The Biology of Extracellular Molecular Chaperones. To get started finding The Biology of Extracellular Molecular Chaperones, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

Pages: 248

Format: PDF, EPUB & Kindle Edition

Publisher: Wiley

Release: 2008

ISBN: 0470754028

Description: The heat shock, or cell stress, response was first identified in the polytene chromosomes of "Drosophila." This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.Since the promulgation of the 'molecular chaperone' concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.This is the first book bringing leading researchers in this field together to review and discuss: our current knowledge of cell stress response and molecular chaperonesthe changing paradigms of protein trafficking and functioncell stress proteins as immunomodulators and pro- and anti-inflammatory signalling moleculesthe role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents."The Biology of Extracellular Molecular Chaperones" is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with The Biology of Extracellular Molecular Chaperones. To get started finding The Biology of Extracellular Molecular Chaperones, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

Special Offer | $0.00

Special Offer! | $0.00

The Biology of Extracellular Molecular Chaperones

The Biology of Extracellular Molecular Chaperones

More Books